Kannemeyer was born in 1967 in Cape Town and lives there. He completed an MFA at the University of Stellenbosch in 1997. Together with Conrad Botes, he has been at the forefront of introducing a comic and satirical aesthetic to South African art. He and Botes were the co-founders and are the ongoing co-editors of the Bitterkomix series, which started in 1992 and has become revered for its subversive stance and dark humour.
Kannemeyer has held seven solo shows at Stevenson in Johannesburg and Cape Town between 2008 and 2015. Group exhibitions include Chaos: Winter 2015 Collected Works at the Rennie Collection in Vancouver (2016); Kaboom: African Comics in Focus at the Basler Afrika Bibliographien in Basel (2015); Africa: Architecture, Culture and Identity at the Louisiana Museum of Modern Art, Humlebæk (2015); Public Intimacy: Art and Other Ordinary Acts in South Africa at the Yerba Buena Center for the Arts, San Francisco (2014); Taboo at the Museum of Contemporary Art Australia, Sydney (2012); Impressions from South Africa, 1965 to Now at the Museum of Modern Art, New York (2011); and in 2010; Les Afriques de Papa at l'Espace du Collectif Sadi in Kinshasa, DR Congo; ... for those who live in it: Pop culture, politics and strong voices at MU Eindhoven; and The Graphic Unconscious as part of Philagrafika 2010 at The Print Center in Philadelphia.
Kannemeyer has published a number of books including Pappa in Doubt (Jacana, 2015); The Erotic Drawings of Anton Kannemeyer (Stevenson, 2014); Alphabet of Democracy (Jacana, 2010); and Pappa in Afrika (Jacana, 2010), which won the best foreign graphic novel prize at Amadora's International Comic Festival in Portugal in 2015.