Ndzube was born in 1990 in Hofmeyr, Eastern Cape, and lives in Los Angeles. He has a BA Fine Art from the Michaelis School of Fine Art, University of Cape Town.

Oracles of the Pink Universe, the artist's first institutional solo exhibition in the United States, took place at the Denver Art Museum in 2021. Previous solo exhibitions have taken place at Museo Kaluz (2019); CC Foundation, Shanghai (2018) alongside Nicodim Gallery (2017-2022), and Stevenson (2019-2022).

Notable group exhibitions include Boil, Toil and Trouble, Art in Common, Los Angeles USA (2023); Pacific Gold, California Biennial, Orange County Museum of Art, USA (2023); Abrasive Paradise, Kunsthal KAde, Amersfoort (2022); In Some Form or Fashion, The Momentary, Arkansas (2021); Lineages: Works from the Collection, NSU Art Museum, Fort Lauderdale (2021); Shattered Glass, Jeffrey Deitch, Los Angeles (2021); Witness: Afro Perspectives from the Jorge M Pérez Collection, El Espacio 23, Miami (2020); A Fair Share of Utopia, Nest, the Netherlands (2020); Là où les eaux se mêlent (where water comes together with other water), the 15th Lyon Biennale (2019); Open Borders the 14th Curitiba International Biennial, Brazil (2019); People at Jeffrey Deitch, Los Angeles (2019); New Acquisitions, Rubell Family Collection, Miami (2019); Hacer Noche (Crossing Night) in Oaxaca, Mexico (2018); The Eye Sees Not Itself, Nicodim Gallery, Los Angeles (2017); Hierophant, Nicodim Gallery, Bucharest (2017); Women's Work, Iziko South African National Gallery, Cape Town (2016); Our Lady, Iziko South African National Gallery (2016); The Art of Disruptions, Iziko South African National Gallery (2016); #theopening, Greatmore Studios, Cape Town (2016); Kasi-2-Kasi Public Arts Festival as part of Remaking Place, Gordon Institute for Performing & Creative Arts, Cape Town (2015); Revisiting the Latent Archive in Sites, The Hostel, Cape Town (2015) and Peter Clarke and Friends, Frank Joubert Art Centre.

Ndzube has completed residencies at Dalton Warehouse Studios, South Central, Los Angeles (2018) and Greatmore Studios, Woodstock Cape Town (2016). He is the recipient of the Culture Creators 'Innovators & Leaders' Award in Art (2019), the Tollman Award for Visual Art (2016), the Michaelis Prize (2015), the Simon Gerson Prize (2015) and the Cecil Skotnes Scholarship (2013) at UCT.

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